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Article

Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex.

Neural development - 16 Jan 2009

Ivaniutsin Uladzislau, Chen Yijing, Mason John O, Price David J, Pratt Thomas

Abstract excerpt

BACKGROUND: Adenomatous polyposis coli (Apc) is a large multifunctional protein known to be important for Wnt/beta-catenin signalling, cytoskeletal dynamics, and cell polarity. In the developing cerebral cortex, Apc is expressed in proliferating cells and its expression increases as cells migrate to the cortical plate. We examined the consequences of loss of Apc function for the early development of the cerebral...

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Identifiers

PMID: 19149881
DOI: 10.1186/1749-8104-4-3
PMCID: PMC2649069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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