Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A glucocorticoid receptor gene haplotype (TthIII1/ER22/23EK/9beta) is associated with a more aggressive disease course in multiple sclerosis.

The Journal of clinical endocrinology and metabolism - 1 Jun 2009

van Winsen Lisa M L, Manenschijn Laura, van Rossum Elisabeth F C, Crusius J Bart A, Crusius Bart A, Koper Jan Willem, Polman Chris H, Uitdehaag Bernard M J

Abstract excerpt

CONTEXT: In patients with multiple sclerosis (MS), glucocorticoids (GCs) might not be sufficiently able to restrain the immune system, possibly due to decreased GC sensitivity. This may be, at least partially, genetically determined. Previously, we reported a more aggressive disease course in patients with the glucocorticoid receptor (GR) gene ER22/23EK polymorphism, which has been shown to decrease GC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to Multiple Sclerosis

Share to Polymorphism, Genetic

Share to Receptors, Glucocorticoid

Source

Identifiers

PMID: 19318444
DOI: 10.1210/jc.2008-2194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A glucocorticoid receptor gene haplotype (TthIII1/ER22/23EK/9beta) is associated with a more aggressive disease course in multiple sclerosis.PMID 19318444Read ↗

Glucocorticoid receptor gene polymorphisms associated with more aggressive disease phenotype in MS.Semantic proximity Read ↗

Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis.Semantic proximity Read ↗

Glucocorticoid receptor gene polymorphisms in Guillain-Barré syndrome.Semantic proximity Read ↗

Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphismsSemantic proximity Read ↗

Glucocorticoid receptor polymorphism affects transrepression but not transactivation.Semantic proximity Read ↗

The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis.Semantic proximity Read ↗

Sequencing analysis of the human glucocorticoid receptor (NR3C1) gene in multiple sclerosis patients.Semantic proximity Read ↗

Genetic glucocorticoid receptor variants differ between ethnic groups but do not explain variation in age of diabetes onset, metabolic and inflammation parameters in patients with type 2 diabetes.Semantic proximity Read ↗

Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.Semantic proximity Read ↗

A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.Semantic proximity Read ↗

Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men.Semantic proximity Read ↗

Effect of glucocorticoid receptor gene polymorphisms in Guillain-Barré syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.