Article
Glucocorticoid receptor polymorphism affects transrepression but not transactivation.
The Journal of clinical endocrinology and metabolism - 1 Jul 2006
van den Akker Erica L T, Russcher Henk, van Rossum Elisabeth F C, Brinkmann Albert O, de Jong Frank H, Hokken Anita, Pols Huibert A P, Koper Jan W, Lamberts Steven W J
Abstract excerpt
CONTEXT: Glucocorticoids (GCs) are extensively used in the treatment of inflammatory and autoimmune diseases. Their beneficial effects are thought to be mediated by GC transrepression on gene expression. However, their use is limited by serious adverse effects, presumably mediated by GC transactivation of gene expression. OBJECTIVE: The objective of the study was to investigate the effect of the GC receptor...
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