Article
Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis.
Arthritis research & therapy - 1 Jan 2010
van Oosten Manon J M, Dolhain Radboud J E M, Koper Jan W, van Rossum Elisabeth F C, Emonts Marieke, Han Khik H, Wouters Jacques M G W, Hazes Johanne M W, Lamberts Steven W J, Feelders Richard A
Abstract excerpt
INTRODUCTION: The glucocorticoid receptor (GR) plays an important regulatory role in the immune system. Four polymorphisms in the GR gene are associated with differences in glucocorticoid (GC) sensitivity; the minor alleles of the polymorphisms N363 S and BclI are associated with relative hyperse...
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