Article
Effect of glucocorticoid receptor gene polymorphisms in Guillain-Barré syndrome.
Journal of the peripheral nervous system : JPNS - 1 Jun 2009
Dekker Marieke J H J, van den Akker Erica L T, Koper Jan Willem, Manenschijn Laura, Geleijns Karin, Ruts Liselotte, van Rijs Wouter, Tio-Gillen Anne P, van Doorn Pieter A, Lamberts Steven W J, Jacobs Bart C
Abstract excerpt
Guillain-Barré syndrome (GBS) is a postinfectious immune-mediated polyneuroradiculopathy in which host factors influence disease susceptibility and clinical course. Single-nucleotide polymorphisms (SNPs) in the glucocorticoid receptor (GR) gene influence the sensitivity to glucocorticoids and are related to both microbial colonization and susceptibility to develop auto-immune disease. This genetic variation may...
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