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Article

Glucocorticoid receptor gene polymorphisms associated with more aggressive disease phenotype in MS.

Journal of neuroimmunology - 1 May 2007

van Winsen L M L, Hooper-van Veen T, van Rossum E F C, Koper J W, Barkhof F, Polman C H, Uitdehaag B M J

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system, in which unknown environmental factors are thought to trigger disease in genetically susceptible persons. Glucocorticoids (GCs) play an important role in controlling chronic inflammatory diseases, like MS. Three polymorphisms in the glucocorticoid receptor (GR) gene (N363S, ER22/23EK and the Bcl I C/G) have...

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Identifiers

PMID: 17395275
DOI: 10.1016/j.jneuroim.2007.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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