Article
Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.
The Journal of clinical endocrinology and metabolism - 1 Oct 2005
Russcher Henk, Smit Pauline, van den Akker Erica L T, van Rossum Elisabeth F C, Brinkmann Albert O, de Jong Frank H, Lamberts Steven W J, Koper Jan W
Abstract excerpt
CONTEXT: Interindividual variation in glucocorticoid (GC)-sensitivity can be partly explained by polymorphisms in the GC receptor (GR) gene. The ER22/23EK and N363S polymorphisms have been described to be associated with lower and higher GC sensitivity, respectively. OBJECTIVE AND DESIGN: We examined the basis of this altered GC sensitivity by expressing GR(N363S) and GR(ER22/23EK) in COS-1 cells and...
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