Article
The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis.
Journal of neuroimmunology - 1 Oct 2005
van Winsen Lisa L M, Hooper-van Veen Tineke, van Rossum Elisabeth F C, Polman Chris H, van den Berg Timo K, Koper Jan W, Uitdehaag Bernard M J
Abstract excerpt
Glucocorticoid (GC) sensitivity varies considerably in healthy controls as well as in patients with chronic inflammatory diseases like multiple sclerosis (MS). We investigated whether polymorphisms in the glucocorticoid receptor (N363S, ER22/23EK, and the BclI) were responsible for altered GC sensitivity. In healthy controls we found an association between the N363S allele of the GR and a reduced peripheral GC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.