Article
KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice.
Molecular biology reports - 1 Mar 2010
Pan Qin, Ma Jun, Zhou Qinshu, Li Jun, Tang Yongqing, Liu Yi, Yang Yiqing, Xiao Junjie, Peng Luying, Li Pengjuan, Liang Dandan, Zhang Hong, Chen Yi-Han
Abstract excerpt
The KCNQ1 channel is abundantly expressed in the gastric parietal cells. Although the functional coupling of KCNQ1 with the H(+)/K(+)-ATPase has already been confirmed on the basis of pharmacological kinetics, the effect of a KCNQ1 loss-of-function mutation on gastric acidification remains unclear. In this study, parietal cells and gastric glands from both C57BL/6 J mice (normal control) and J343 mice (mice with...
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