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Article

Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3.

Journal of gastroenterology - 1 Oct 2010

Rotte Anand, Pasham Venkanna, Eichenmüller Melanie, Yang Wenting, Qadri Syed M, Bhandaru Madhuri, Lang Florian

Abstract excerpt

BACKGROUND: According to previous observations, basal gastric acid secretion is downregulated by phosphoinositol-3-(PI3)-kinase, phosphoinositide-dependent kinase (PDK1), and protein kinase B (PKBβ/Akt2) signaling. PKB/Akt phosphorylates glycogen synthase kinase GSK3. The present study explored whether PKB/Akt-dependent GSK3-phosphorylation modifies gastric acid secretion. METHODS: Utilizing...

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Source

Identifiers

PMID: 20552232
DOI: 10.1007/s00535-010-0260-2

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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