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Article

Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger.

The Journal of biological chemistry - 1 Apr 2005

Gawenis Lara R, Greeb Jeannette M, Prasad Vikram, Grisham Christina, Sanford L Philip, Doetschman Thomas, Andringa Anastasia, Miller Marian L, Shull Gary E

Abstract excerpt

The NHE4 Na+/H+ exchanger is abundantly expressed on the basolateral membrane of gastric parietal cells. To test the hypothesis that it is required for normal acid secretion, NHE4-null mutant (NHE4-/-) mice were prepared by targeted disruption of the NHE4 (Slc9a4) gene. NHE4-/- mice survived and appeared outwardly normal. Analysis of stomach contents revealed that NHE4-/- mice were hypochlorhydric. The reduction...

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PMID: 15684419
DOI: 10.1074/jbc.M414118200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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