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Article

Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice.

The journal of physiological sciences : JPS - 1 Jan 2009

Kanai Setsuko, Hosoya Hiroko, Akimoto Saeko, Ohta Minoru, Matsui Toshimitsu, Takiguchi Soichi, Funakoshi Akihiro, Miyasaka Kyoko

Abstract excerpt

Gastrin is important for stimulating acid secretion as well as differentiating gastric mucosal cells via cholecystokinin-2 receptors (CCK-2Rs). In turn, CCK acts preferably via CCK-1R to release somatostatin, and somatostatin has been postulated to exhibit a tonic inhibition of gastrin bioactivity. The present study was designed to examine the hypothesis that CCK-1R and 2R may act in opposite directions in...

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Identifiers

PMID: 19340558
DOI: 10.1007/s12576-008-0001-y
PMCID: PMC10717123

Genes

CCK

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