Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice.

Human molecular genetics - 15 Nov 2004

Elso Colleen M, Lu Xiaochen, Culiat Cymbeline T, Rutledge Joe C, Cacheiro Nestor L A, Generoso Walderico M, Stubbs Lisa J

Abstract excerpt

Increased susceptibility to gastric cancer has been associated with a wide range of host genetic and environmental factors, including Helicobacter pylori infection. Helicobacter pylori infection is postulated to initiate a progression through atrophic gastritis, metaplasia and dysplasia to cancer, and has been associated with reduction of acid output and dysregulation of stomach mucins. Here, we present the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Gastritis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Helicobacter Infections

Share to Hyperplasia

Share to KCNQ Potassium Channels

Share to Metaplasia

Share to Mice, Inbred C3H

Share to Precancerous Conditions

Source

Identifiers

PMID: 15385447
DOI: 10.1093/hmg/ddh307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice.PMID 15385447Read ↗

Diet-Induced Obesity Exacerbates <i>Helicobacter pylori</i> -Associated Precancerous PhenotypesSemantic proximity Read ↗

KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice.Semantic proximity Read ↗

Comparison of gastric inflammation and metaplasia induced by Helicobacter pylori or Helicobacter felis colonization in miceSemantic proximity Read ↗

Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.Semantic proximity Read ↗

The role of KCNQ1 in mouse and human gastrointestinal cancers.Semantic proximity Read ↗

Mouse Models of Gastric CarcinogenesisSemantic proximity Read ↗

Chronic Helicobacter pylori infections induce gastric mutations in mice.Semantic proximity Read ↗

Chronic cigarette smoke exposure masks pathological features of <i>Helicobacter pylori</i> infection while promoting tumor initiationSemantic proximity Read ↗

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.Semantic proximity Read ↗

p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice.Semantic proximity Read ↗

How useful are the rodent animal models of gastric adenocarcinoma?Semantic proximity Read ↗

The MUC1 mucin protects against <i>Helicobacter pylori</i> pathogenesis in mice by regulation of the NLRP3 inflammasomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.