Article
Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf.
The Journal of biological chemistry - 17 Sept 1999
Flagella M, Clarke L L, Miller M L, Erway L C, Giannella R A, Andringa A, Gawenis L R, Kramer J, Duffy J J, Doetschman T, Lorenz J N, Yamoah E N, Cardell E L, Shull G E
Abstract excerpt
In chloride-secretory epithelia, the basolateral Na-K-2Cl cotransporter (NKCC1) is thought to play a major role in transepithelial Cl(-) and fluid transport. Similarly, in marginal cells of the inner ear, NKCC1 has been proposed as a component of the entry pathway for K(+) that is secreted into t...
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