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Article

Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T.

The Journal of general physiology - 1 Jul 2010

Iovannisci David, Illek Beate, Fischer Horst

Abstract excerpt

Airways secrete considerable amounts of acid. In this study, we investigated the identity and the pH-dependent function of the apical H(+) channel in the airway epithelium. In pH stat recordings of confluent JME airway epithelia in Ussing chambers, Zn-sensitive acid secretion was activated at a mucosal threshold pH of approximately 7, above which it increased pH-dependently at a rate of 339 +/- 34 nmol x h(-1) x...

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Source

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Identifiers

PMID: 20548053
DOI: 10.1085/jgp.200910379
PMCID: PMC2894549

Genes

HVCN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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