Article
Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum.
Gastroenterology - 1 Oct 2004
Hirokawa Masahiko, Takeuchi Tetsu, Chu Sahaoyou, Akiba Yasutada, Wu Vincent, Guth Paul H, Engel Eli, Montrose Marshall H, Kaunitz Jonathan D
Abstract excerpt
BACKGROUND & AIMS: Dysfunction of the cystic fibrosis transmembrane regulator (CFTR) is associated with diminished duodenal HCO3- secretion, despite a reported lack of clinical duodenal ulceration in affected subjects. We hypothesized that duodenal epithelial cells expressing a mutant CFTR have e...
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