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Article

Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric.

The Journal of biological chemistry - 16 Jul 2004

Gawenis Lara R, Ledoussal Clara, Judd Louise M, Prasad Vikram, Alper Seth L, Stuart-Tilley Alan, Woo Alison L, Grisham Christina, Sanford L Philip, Doetschman Thomas, Miller Marian L, Shull Gary E

Abstract excerpt

The AE2 Cl-/HCO3- exchanger is expressed in numerous cell types, including epithelial cells of the kidney, respiratory tract, and alimentary tract. In gastric epithelia, AE2 is particularly abundant in parietal cells, where it may be the predominant mechanism for HCO3- efflux and Cl- influx across the basolateral membrane that is needed for acid secretion. To investigate the hypothesis that AE2 is critical for...

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PMID: 15123620
DOI: 10.1074/jbc.M403779200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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