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Article

Utilization of knockout mice to examine the potential role of gastric histamine H2-receptors in Menetrier's disease.

Journal of pharmacological sciences - 1 Jan 2003

Ogawa Toshiki, Maeda Kazuhiko, Tonai Shunsuke, Kobayashi Takashi, Watanabe Takeshi, Okabe Susumu

Abstract excerpt

Menetrier's disease is characterized by giant gastric folds with foveolar hyperplasia and cystic dilatation, hypoproteinemia, and enhanced mucus secretion. The etiology remains unresolved and an effective treatment has yet to be established. Here we show that histamine H(2)-receptor deficient mice developed gastric pathophysiological changes resembling Menetrier's disease for up to 17 months of observation....

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Source

Identifiers

PMID: 12686732
DOI: 10.1254/jphs.91.61

Genes

CCK
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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