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Article

Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine.

Pharmacogenetics and genomics - 1 May 2009

Swan Gary E, Lessov-Schlaggar Christina N, Bergen Andrew W, He Yungang, Tyndale Rachel F, Benowitz Neal L

Abstract excerpt

OBJECTIVES: The ratio of trans-3'hydroxycotinine/cotinine (3HC/COT) is a marker of CYP2A6 activity, an important determinant of nicotine metabolism. This analysis sought to conduct a combined genetic epidemiologic and pharmacogenetic investigation of the 3HC/COT ratio in plasma and urine. METHODS: One hundred and thirty-nine twin pairs [110 monozygotic and 29 dizygotic] underwent a 30-min infusion of stable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2A6

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Source

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Identifiers

PMID: 19300303
DOI: 10.1097/FPC.0b013e32832a404f
PMCID: PMC2849278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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