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Article

Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies.

Drug and alcohol dependence - 1 Jun 2021

Giratallah Haidy K, Chenoweth Meghan J, Addo Newton, Ahluwalia Jasjit S, Cox Lisa Sanderson, Lerman Caryn, George Tony P, Benowitz Neal L, Tyndale Rachel F

Abstract excerpt

BACKGROUND: Variation in CYP2A6 activity influences tobacco smoking behaviors and smoking-related health outcomes. Plasma Nicotine Metabolite Ratio (NMR) is a robust phenotypic biomarker of CYP2A6 activity and nicotine clearance. In urine, the NMR has been calculated as a ratio of free trans-3'-hydroxycotinine to free cotinine (NMRF/F), total trans-3'-hydroxycotinine to free cotinine (NMRT/F), or total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33873029
DOI: 10.1016/j.drugalcdep.2021.108708
PMCID: PMC8133391

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