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Article

Sex dependent genetic architecture of biochemically verified tobacco use.

Psychiatry research - 1 Jun 2025

Chenoweth Meghan J, Lerman Caryn, Knight Jo, Tyndale Rachel F

Abstract excerpt

BACKGROUND: Tobacco use differs by genetics and sex, and dose-dependently increases the risk for numerous diseases. Nicotine is metabolized to cotinine (COT) which is further metabolized to 3'hydroxycotinine (3HC). COT and COT+3HC are biomarkers which capture tobacco intake more accurately than self-reported measures such as cigarettes/day. It is currently not known whether genetic risk factors for heavier...

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Identifiers

PMID: 40174410
DOI: 10.1016/j.psychres.2025.116465
PMCID: PMC13196733

Genes

HSPA13
SPOCK3

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