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Article

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2014

Chenoweth Meghan J, Novalen Maria, Hawk Larry W, Schnoll Robert A, George Tony P, Cinciripini Paul M, Lerman Caryn, Tyndale Rachel F

Abstract excerpt

BACKGROUND: The ratio of 3'hydroxycotinine to cotinine, or nicotine metabolite ratio (NMR), is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine metabolism, and nicotine clearance. Higher NMR (faster nicotine clearance) is associated retrospectively with heavier smoking and lower cessation rates. METHODS: NMR as a predictive biomarker of cessation outcomes is being investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25012994
DOI: 10.1158/1055-9965.EPI-14-0427
PMCID: PMC4154993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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