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Article

Genetic influences in the variation in renal clearance of nicotine and cotinine.

Clinical pharmacology and therapeutics - 1 Aug 2008

Benowitz N L, Lessov-Schlaggar C N, Swan G E

Abstract excerpt

Nicotine and its proximate metabolite cotinine are eliminated in part by renal clearance. These compounds are filtered, secreted, and reabsorbed, and the resultant renal clearances are quite variable among individuals and are highly influenced by urine pH. In this study of 139 pairs of twins, we have estimated the genetic and environmental contributions to total renal clearance and net secretory/reabsorptive...

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Source

Identifiers

PMID: 18388871
DOI: 10.1038/clpt.2008.54

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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