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Article

Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.

PloS one - 1 Jan 2013

Zhu Andy Z X, Zhou Qian, Cox Lisa Sanderson, Ahluwalia Jasjit S, Benowitz Neal L, Tyndale Rachel F

Abstract excerpt

BACKGROUND: CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3'-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CYP2A6 mediated nicotine metabolism, and total nicotine clearance, and has been associated with differences in numerous smoking behaviors. The clearance of...

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Source

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Identifiers

PMID: 23936477
DOI: 10.1371/journal.pone.0070938
PMCID: PMC3732272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.PMID 23936477Read ↗

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