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Article

Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence.

Pharmacogenetics and genomics - 1 Feb 2005

Swan Gary E, Benowitz Neal L, Lessov Christina N, Jacob Peyton, Tyndale Rachel F, Wilhelmsen Kirk

Abstract excerpt

To conduct a pharmacogenetic investigation of nicotine metabolism in twins. One hundred and thirty nine twin pairs [110 monozygotic (MZ) and 29 dizygotic (DZ)] underwent a 30-min infusion of stable isotope-labelled nicotine and its major metabolite, cotinine, followed by an 8-h in-hospital stay. Blood and urine samples were taken at regular intervals for analysis of nicotine, cotinine and metabolites by gas...

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Source

Identifiers

PMID: 15861035
DOI: 10.1097/01213011-200502000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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