Article
Crystal structure of the extracellular segment of integrin alpha Vbeta3.
Science (New York, N.Y.) - 12 Oct 2001
Xiong J P, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott D L, Joachimiak A, Goodman S L, Arnaout M A
Abstract excerpt
Integrins are alphabeta heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the crystal structure of the extracellular portion of integrin alphaVbeta3 at 3.1 A resolution. Its 12 domains assemble into an ovoid "head" and two "tails." In the crystal, alphaVbeta3 is severely bent at a defined region in...
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