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Article

Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2009

Lee Gwanghee, White Lynn S, Hurov Kristen E, Stappenbeck Thaddeus S, Piwnica-Worms Helen

Abstract excerpt

The CDC25 protein phosphatases (CDC25A, B, and C) drive cell cycle transitions by activating key components of the cell cycle engine. CDC25A and CDC25B are frequently overproduced in human cancers. Disruption of Cdc25B or Cdc25C individually or in combination has no effect on mouse viability. Here we report that CDC25A is the only family member to provide an essential function during early embryonic development,...

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Identifiers

PMID: 19273838
DOI: 10.1073/pnas.0900751106
PMCID: PMC2660721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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