Article
mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans.
Cell research - 1 Nov 2011
Liu Min, Liu Pengpeng, Zhang Li, Cai Qingchun, Gao Ge, Zhang Wenxia, Zhu Zuoyan, Liu Dong, Fan Qichang
Abstract excerpt
MicroRNA (miRNA) regulates gene expression in many cellular events, yet functions of only a few miRNAs are known in C. elegans. We analyzed the function of mir-35-41 unique to the worm, and show here that mir-35 regulates the G1/S transition of intestinal cells and germ cell proliferation. Loss of mir-35 leads to a decrease of nuclei numbers in intestine and distal mitotic gonad, while re-introduction of mir-35...
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