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In Vivo Roles of CDC25 Phosphatases: Biological Insight into the Anti-Cancer Therapeutic Targets

1 Dec 2008

Abstract excerpt

CDC25 phosphatases are not only rate-limiting activators of cyclin-dependent kinases (CDKs) but also important targets of the CHK1/CHK2-mediated checkpoint pathway. Each isoform of the mammalian CDC25 family seems to exert unique biological functions. CDC25A is a critical regulator for both G1-S and G2-M transitions and essential for embryonic cell proliferation after the blastocyst stage. CDC25B is dispensable...

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PMID: 19075565
DOI: 10.2174/187152008786847693

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In Vivo Roles of CDC25 Phosphatases: Biological Insight into the Anti-Cancer Therapeutic TargetsPMID 19075565Read ↗

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CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent mannerSemantic proximity Read ↗

Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development.Semantic proximity Read ↗

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Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expressionSemantic proximity Read ↗

Deregulated CDC25A Expression Promotes Mammary Tumorigenesis with Genomic InstabilitySemantic proximity Read ↗

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