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Cell Cycle Control by the CDC25 Phosphatases

1 Dec 2008

Abstract excerpt

Cell division cycle 25 (CDC25) phosphatases are key actors in eukaryotic cell cycle control. They are responsible for the dephosphorylations that activate the cyclin-dependent kinases (CDK) at specific stages of the cell cycle. Human CDC25A, CDC25B and CDC25C are also central targets and regulators of the G2/M checkpoint mechanisms activated in response to DNA injury. The expression and activity of these enzymes...

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PMID: 19075563
DOI: 10.2174/187152008786847756

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Cell Cycle Control by the CDC25 PhosphatasesPMID 19075563Read ↗

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CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic StabilitySemantic proximity Read ↗

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.Semantic proximity Read ↗

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