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Article

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine.

Molecular biology of the cell - 1 Mar 2010

Segref Alexandra, Cabello Juan, Clucas Caroline, Schnabel Ralf, Johnstone Iain L

Abstract excerpt

Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis. In mammalian cells, as part of a general cell cycle checkpoint mechanism, the F-box protein beta-transducin repeat-containing protein (beta-TrCP) and the Skp1/Cul1/F-box complex control the periodic...

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Identifiers

PMID: 20053685
DOI: 10.1091/mbc.e09-04-0268
PMCID: PMC2828960

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