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Article

Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele.

The EMBO journal - 15 Feb 2002

Clucas Caroline, Cabello Juan, Büssing Ingo, Schnabel Ralf, Johnstone Iain L

Abstract excerpt

In multicellular organisms, developmental programmes must integrate with central cell cycle regulation to co-ordinate developmental decisions with cell proliferation. Hyperplasia caused by deregulated proliferation without significant change to other aspects of developmental behaviour is a probable step towards full oncogenesis in many malignancies. CDC25 phosphatase promotes progression through the eukaryotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11847114
DOI: 10.1093/emboj/21.4.665
PMCID: PMC125848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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