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Article

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.

The Journal of clinical investigation - 1 Mar 2012

Sakamori Ryotaro, Das Soumyashree, Yu Shiyan, Feng Shanshan, Stypulkowski Ewa, Guan Yinzheng, Douard Veronique, Tang Waixing, Ferraris Ronaldo P, Harada Akihiro, Brakebusch Cord, Guo Wei, Gao Nan

Abstract excerpt

The constant self renewal and differentiation of adult intestinal stem cells maintains a functional intestinal mucosa for a lifetime. However, the molecular mechanisms that regulate intestinal stem cell division and epithelial homeostasis are largely undefined. We report here that the small GTPases Cdc42 and Rab8a are critical regulators of these processes in mice. Conditional ablation of Cdc42 in the mouse...

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Identifiers

PMID: 22354172
DOI: 10.1172/JCI60282
PMCID: PMC3287229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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