Article

Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt

2020-10-01

Abstract excerpt

<h4>Summary</h4> The role of individual miRNAs in small intestinal (SI) epithelial homeostasis is under-explored. In this study, we discovered that miR-375 is among the most enriched miRNAs in intestinal crypts and stem cells (ISCs), especially facultative ISCs. We then showed by multiple manipulations, including CRISPR/Cas9 editing, that miR-375 is strongly suppressed by Wnt-signaling. Single-cell RNA-seq analys...

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Literature Corpus work: 8f0d05c2-bfac-50f9-8af6-2d0e733fefe2
DOI: 10.1101/2020.10.01.321612

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