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Article

Hemizygous Disruption of <i>Cdc25A</i> Inhibits Cellular Transformation and Mammary Tumorigenesis in Mice

15 Jul 2007

Abstract excerpt

CDC25A phosphatase activates multiple cyclin-dependent kinases (CDK) during cell cycle progression. Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of DNA damage-induced S-G(2) checkpoint. Although increased CDC25A expression has been reported in various human cancer tissues, it remains unclear whether CDC25A activation is a critical rate-limiting step of carcinogenesis. To assess...

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PMID: 17638870
DOI: 10.1158/0008-5472.can-06-4815

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Hemizygous Disruption of <i>Cdc25A</i> Inhibits Cellular Transformation and Mammary Tumorigenesis in MicePMID 17638870Read ↗

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