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Article

CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic Stability

1 Mar 2008

Abstract excerpt

CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to...

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PMID: 18316586
DOI: 10.1158/0008-5472.can-07-5983

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