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Article

A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis.

Molecular carcinogenesis - 1 Sept 2009

Boman Bruce, Kopelovich Levy, Siracusa Linda D, Zhang Tao, Henderson Kim, Cofer Zenobia, Buchberg Arthur M, Fields Jeremy Z, Otevrel Tomas

Abstract excerpt

Apc mutations cause intestinal tumorigenesis through Tcf4 activation. However, direct techniques for studying Tcf4 activation in vivo are limited. Here, we describe the development of a Tcf4-GFP reporter mouse model for directly studying Tcf4 activation. We first developed a GFP reporter construct (Tcf4-GFP) and transfected it into SW480 cells that have constitutively activated Tcf4. Reporter activity increased...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19263440
DOI: 10.1002/mc.20526
PMCID: PMC10966679

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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