Article

Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine

2017-06-27

Abstract excerpt

<h4>Background & Aims</h4> Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. CF mice exhibit augmented intestinal proliferation of unknown etiology and an altered intestinal environment. We examined the role of Cftr in Wnt/β-catenin signaling, stem cell proliferation and its functional expression in the active intestinal stem cell (ISC) population. Dysregulation of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67cf1cd0-4504-519d-b031-afcdabee270c
DOI: 10.1101/156562

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine IntestineDOI 10.1101/156562Read

CFTR is a tumor suppressor gene in murine and human intestinal cancer.Semantic proximity Read

Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial RegenerationSemantic proximity Read

Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system.Semantic proximity Read

Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cellsSemantic proximity Read

Cystic Fibrosis, CFTR, and Colorectal Cancer.Semantic proximity Read

Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular ComponentsSemantic proximity Read

CFTR and Gastrointestinal Cancers: An UpdateSemantic proximity Read

Wnt/PCP-primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cellsSemantic proximity Read

A Rare T-Cell Factor 4 Lineage-negative Epithelial Stem Cell Supports Wound Repair and APC-deletion-induced Colon TumorigenesisSemantic proximity Read

A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in diseaseSemantic proximity Read

Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells.Semantic proximity Read

Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cellsSemantic proximity Read