Article
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
Cell - 18 Oct 2002
van de Wetering Marc, Sancho Elena, Verweij Cornelis, de Lau Wim, Oving Irma, Hurlstone Adam, van der Horn Karin, Batlle Eduard, Coudreuse Damien, Haramis Anna Pavlina, Tjon-Pon-Fong Menno, Moerer Petra, van den Born Maaike, Soete Gwen, Pals Steven, Eilers Martin, Medema Rene, Clevers Hans
Abstract excerpt
The transactivation of TCF target genes induced by Wnt pathway mutations constitutes the primary transforming event in colorectal cancer (CRC). We show that disruption of beta-catenin/TCF-4 activity in CRC cells induces a rapid G1 arrest and blocks a genetic program that is physiologically active in the proliferative compartment of colon crypts. Coincidently, an intestinal differentiation program is induced. The...
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