Article
Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development.
The American journal of pathology - 1 Dec 2010
Zhang Tao, Fields Jeremy Z, Opdenaker Lynn, Otevrel Tomas, Masuda Emi, Palazzo Juan P, Isenberg Gerald A, Goldstein Scott D, Brand Marc, Boman Bruce M
Abstract excerpt
APC mutations initiate most colorectal cancers (CRCs), but cellular mechanisms linking this to CRC pathology are unclear. We reported that wild-type APC in the colon down-regulates the anti-apoptotic protein survivin, and APC mutation up-regulates it, explaining why most CRCs display survivin overexpression and apoptosis inhibition. However, it does not explain another hallmark of CRC pathology--increased mitotic...
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