Article
CFTR is a tumor suppressor gene in murine and human intestinal cancer.
Oncogene - 11 Aug 2016
Than B L N, Linnekamp J F, Starr T K, Largaespada D A, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemczyk A, O'Sullivan M G, Medema J P, Fijneman R J A, Meijer G A, Van den Broek E, Hodges C A, Scott P M, Vermeulen L, Cormier R T
Abstract excerpt
CFTR, the cystic fibrosis (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue homeostasis of various epithelia. In the gastrointestinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playing an essential role in ion and acid-base homeostasis. Cftr has been identified as a candidate driver gene for colorectal cancer (CRC) in several Sleeping Beauty DNA...
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