Article
Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2017
Hashimoto Kyoichi, Yamada Yosuke, Semi Katsunori, Yagi Masaki, Tanaka Akito, Itakura Fumiaki, Aoki Hitomi, Kunisada Takahiro, Woltjen Knut, Haga Hironori, Sakai Yoshiharu, Yamamoto Takuya, Yamada Yasuhiro
Abstract excerpt
The spectrum of genetic mutations differs among cancers in different organs, implying a cellular context-dependent effect for genetic aberrations. However, the extent to which the cellular context affects the consequences of oncogenic mutations remains to be fully elucidated. We reprogrammed colon tumor cells in an ApcMin/+ (adenomatous polyposis coli) mouse model, in which the loss of the Apc gene plays a...
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