Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

1 Oct 2017

Abstract excerpt

Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development. Although extensively studied in epithelial transformation, the effect of APC on T lymphocyte activation remains poorly defined. We found that APC ensures T cell receptor-triggered activation through Nuclear Factor of Activated T cells (NFAT), since APC is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28978472
DOI: 10.1016/j.celrep.2017.09.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT LocalizationPMID 28978472Read ↗

Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.Semantic proximity Read ↗

Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice.Semantic proximity Read ↗

The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration. Insights from familial polyposis patientsSemantic proximity Read ↗

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisationSemantic proximity Read ↗

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation.Semantic proximity Read ↗

The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.Semantic proximity Read ↗

Altered T-Cell Balance in Lymphoid Organs of a Mouse Model of Colorectal Cancer.Semantic proximity Read ↗

New perspectives on APC control of cell fate and proliferation in colorectal cancerSemantic proximity Read ↗

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations.Semantic proximity Read ↗

Microbial Invasion and Immunosuppression Drive Adenoma Progression in Early Colorectal Cancer DevelopmentSemantic proximity Read ↗

Adenomatous polyposis coli in cancer and therapeutic implicationsSemantic proximity Read ↗

Biology of the adenomatous polyposis coli tumor suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.