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Article

A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.

Nature communications - 2 Dec 2019

Boone Peter G, Rochelle Lauren K, Ginzel Joshua D, Lubkov Veronica, Roberts Wendy L, Nicholls P J, Bock Cheryl, Flowers Mei Lang, von Furstenberg Richard J, Stripp Barry R, Agarwal Pankaj, Borowsky Alexander D, Cardiff Robert D, Barak Larry S, Caron Marc G, Lyerly H Kim, Snyder Joshua C

Abstract excerpt

Field cancerization is a premalignant process marked by clones of oncogenic mutations spreading through the epithelium. The timescales of intestinal field cancerization can be variable and the mechanisms driving the rapid spread of oncogenic clones are unknown. Here we use a Cancer rainbow (Crainbow) modelling system for fluorescently barcoding somatic mutations and directly visualizing the clonal expansion and...

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Source

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Identifiers

PMID: 31792216
DOI: 10.1038/s41467-019-13330-y
PMCID: PMC6889384

Genes

RSPO3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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