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Article

HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2021

Murray Elisa, Cheng Xiaoqing, Krishna Anagha, Jin Xiaohua, Ohara Takahiro E, Stappenbeck Thaddeus S, Bose Ron

Abstract excerpt

BACKGROUND AND AIMS: The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. In addition to HER2 mutations, colon cancer patients also possess co-occurring mutations in genes such as APC. Here, we investigated the role of HER2 and APC mutations on the crypt-villus architecture of the intestinal epithelium, localization of secretory cells, and expression of...

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Identifiers

PMID: 33930605
DOI: 10.1016/j.jcmgh.2021.04.012
PMCID: PMC8350008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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