Article
HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Murray Elisa, Cheng Xiaoqing, Krishna Anagha, Jin Xiaohua, Ohara Takahiro E, Stappenbeck Thaddeus S, Bose Ron
Abstract excerpt
BACKGROUND AND AIMS: The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. In addition to HER2 mutations, colon cancer patients also possess co-occurring mutations in genes such as APC. Here, we investigated the role of HER2 and APC mutations on the crypt-villus architecture of the intestinal epithelium, localization of secretory cells, and expression of...
Topics
- Adenomatous Polyposis Coli Protein
- Animals
- Gene Editing
- Hyperplasia
- Intestinal Mucosa
- Matrix Metalloproteinase 7
- Mice
- Mice, Transgenic
- Mucin-2
- Mutation
- Receptor, ErbB-2