Article

A Rare T-Cell Factor 4 Lineage-negative Epithelial Stem Cell Supports Wound Repair and APC-deletion-induced Colon Tumorigenesis

2026-03-18

Abstract excerpt

<h4>Summary</h4> To maintain barrier homeostasis, the colonic and intestinal epithelial lining is continually renewed by rapidly proliferating epithelial crypt base columnar (CBC) stem cells that reside at the base of crypts. Using mouse lineage tracing, immunohistochemistry, and single-cell sequencing, we have identified a rare, non-CBC, T-cell factor 4 lineage-negative ( Tcf4 Lin-) stem cell population that gi...

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Literature Corpus work: 58ca17c4-cbb0-5cce-8c6f-7dab7eddc7b8
DOI: 10.64898/2026.03.17.712502

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