Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypes of mutations in the 5'-UTR of a limiting transcription factor in Aspergillus nidulans can be accounted for by translational inhibition and leaky scanning.

Genetics - 1 Apr 2009

Oestreicher Nathalie, Scazzocchio Claudio

Abstract excerpt

The uaY gene encodes the transcriptional activator of purine catabolism genes in Aspergillus nidulans. uaY12 results in strongly defective growth on purines as nitrogen sources and in strongly diminished transcription of UaY-regulated genes. This mutation introduces an ATG codon 64 bp upstream of the uaY ATG, generating a 68-codon open reading frame (uORFA), overlapping with the uaY ORF. uaY12 revertants fall...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Aspergillus nidulans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Gene Expression Regulation, Fungal

Share to Mutant Proteins

Share to Open Reading Frames

Share to Organisms, Genetically Modified

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 19221200
DOI: 10.1534/genetics.108.099515
PMCID: PMC2666497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypes of mutations in the 5'-UTR of a limiting transcription factor in Aspergillus nidulans can be accounted for by translational inhibition and leaky scanning.PMID 19221200Read ↗

A single amino acid change in a pathway-specific transcription factor results in differing degrees of constitutivity, hyperinducibility and derepression of several structural genes.Semantic proximity Read ↗

Molecular cloning of the uaY regulatory gene of Aspergillus nidulans reveals a favoured region for DNA insertions.Semantic proximity Read ↗

Inhibiting ribosome assembly and ribosome translation have distinctly different effects on the abundance and paralogue composition of ribosomal protein mRNAs in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

A systematic study of gene expression variation at single-nucleotide resolution reveals widespread regulatory roles for uAUGs.Semantic proximity Read ↗

Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.Semantic proximity Read ↗

The uaY positive control gene of Aspergillus nidulans: fine structure, isolation of constitutive mutants and reversion patterns.Semantic proximity Read ↗

Misactivation of multiple starvation responses in yeast by loss of tRNA modifications.Semantic proximity Read ↗

Loss of a conserved tRNA anticodon modification perturbs cellular signaling.Semantic proximity Read ↗

Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.Semantic proximity Read ↗

Combined tRNA modification defects impair protein homeostasis and synthesis of the yeast prion protein Rnq1.Semantic proximity Read ↗

A yeast tRNA mutant that causes pseudohyphal growth exhibits reduced rates of CAG codon translation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.