Article
Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.
Nucleic acids research - 1 Jan 2005
Magazinnik Tanya, Anand Monika, Sattlegger Evelyn, Hinnebusch Alan G, Kinzy Terri Goss
Abstract excerpt
Genetic screens in Saccharomyces cerevisiae have identified the roles of ribosome components, tRNAs and translation factors in translational fidelity. These screens rely on the suppression of altered start codons, nonsense codons or frameshift mutations in genes involved in amino acid or nucleotide metabolism. Many of these genes are regulated by the General Amino Acid Control (GAAC) pathway. Upon amino acid...
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