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Article

Combined tRNA modification defects impair protein homeostasis and synthesis of the yeast prion protein Rnq1.

Prion - 2 Jan 2017

Schaffrath Raffael, Klassen Roland

Abstract excerpt

Modified nucleosides in tRNA anticodon loops such as 5-methoxy-carbonyl-methyl-2-thiouridine (mcm5s2U) and pseuduridine (Ψ) are thought to be required for an efficient decoding process. In Saccharomyces cerevisiae, the simultaneous presence of mcm5s2U and Ψ38 in tRNAGlnUUG was shown to mediate efficient synthesis of the Q/N rich [PIN+] prion forming protein Rnq1. 1 In the absence of these two tRNA modifications,...

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Identifiers

PMID: 28281930
DOI: 10.1080/19336896.2017.1284734
PMCID: PMC5360143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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