Article
Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.
The Journal of biological chemistry - 14 Apr 1995
Diallinas G, Gorfinkiel L, Arst H N, Cecchetto G, Scazzocchio C
Abstract excerpt
In Aspergillus nidulans, loss-of-function mutations in the uapA and azgA genes, encoding the major uric acid-xanthine and hypoxanthine-adenine-guanine permeases, respectively, result in impaired utilization of these purines as sole nitrogen sources. The residual growth of the mutant strains is due to the activity of a broad specificity purine permease. We have identified uapC, the gene coding for this third...
Topics
- Amino Acid Sequence
- Aspergillus nidulans
- Base Sequence
- Cloning, Molecular
- Conserved Sequence
- DNA, Fungal
- Genes, Fungal
- Membrane Transport Proteins
- Molecular Sequence Data
- Mutation